San Francisco 49ers Odds, Spread & Total Points Opening Odds Today

San Francisco 49ers off the Board

• SFO 49ers at ATL Falcons Opening Odds NFL Week 7 – Sunday 2026
  1:00pm Sunday 25th

  Teams

  Spread

  Total

  Odds

  49ers

  -3

  O 48.5

  -165

  Falcons

  3

  U 48.5

  145

  … SFO 49ers at ATL Falcons Opening Odds NFL Week 7 – Sunday 2026
• WAS Commanders at SFO 49ers Opening Odds NFL Week 6 – Monday 2026
  8:15pm Monday 19th

  Teams

  Spread

  Total

  Odds

  Commanders

  7.5

  O 51.5

  310

  49ers

  -7.5

  U 51.5

  -400

  … WAS Commanders at SFO 49ers Opening Odds NFL Week 6 – Monday 2026
• SFO 49ers at SEA Seahawks Opening Odds NFL Week 5 – Sunday 2026
  4:25pm Sunday 11th

  Teams

  Spread

  Total

  Odds

  49ers

  3

  O 47

  Seahawks

  -3

  U 47

  … SFO 49ers at SEA Seahawks Opening Odds NFL Week 5 – Sunday 2026
• DEN Broncos at SFO 49ers Opening Odds NFL Week 4 – Sunday 2026
  4:25pm Sunday 4th

  Teams

  Spread

  Total

  Odds

  Broncos

  3

  O 48.5

  130

  49ers

  -3

  U 48.5

  -150

  … DEN Broncos at SFO 49ers Opening Odds NFL Week 4 – Sunday 2026
• AZ Cardinals at SFO 49ers Opening Odds NFL Week 3 – Sunday 2026
  4:05pm Sunday 27th

  Teams

  Spread

  Total

  Odds

  Cardinals

  8.5

  O 48

  335

  49ers

  -8.5

  U 48

  -425

  … AZ Cardinals at SFO 49ers Opening Odds NFL Week 3 – Sunday 2026
• SFO 49ers at LA Rams Opening Odds NFL Week 1 – Thursday 2026
  8:35pm Thursday 10th

  Teams

  Spread

  Total

  Odds

  49ers

  3.5

  O 48

  165

  Rams

  -3.5

  U 48

  -195

  … SFO 49ers at LA Rams Opening Odds NFL Week 1 – Thursday 2026
• SFO 49ers at LV Raiders Opening Odds NFL Preseason Week 3 – Thursday 2026
  8:00pm Thursday 27th

  Teams

  Spread

  Total

  Odds

  49ers

  3.5

  O 37.5

  140

  Raiders

  -3.5

  U 37.5

  -160

  … SFO 49ers at LV Raiders Opening Odds NFL Preseason Week 3 – Thursday 2026
• SFO 49ers at LA Chargers Opening Odds NFL Preseason Week 2 – Thursday 2026
  10:00pm Thursday 20th

  Teams

  Spread

  Total

  Odds

  49ers

  1.5

  O 39

  100

  Chargers

  -1.5

  U 39

  -120

  … SFO 49ers at LA Chargers Opening Odds NFL Preseason Week 2 – Thursday 2026
• TN Titans at SFO 49ers Opening Odds NFL Preseason Week 1 – Thursday 2026
  9:00pm Thursday 13th

  Teams

  Spread

  Total

  Odds

  Titans

  -2.5

  O 37.5

  49ers

  2.5

  U 37.5

  … TN Titans at SFO 49ers Opening Odds NFL Preseason Week 1 – Thursday 2026
• 49ers at Seahawks Odds NFL Divisional Rnd – Saturday 2026
  8:00pm Saturday 17th

  49ers

  7

  O 45.5

  305

  Seahawks

  -7

  U 45.5

  -375

  … 49ers at Seahawks Odds NFL Divisional Rnd – Saturday 2026